Current position and professional experiences
2000 ~
Professor, Royal Institute of Technology (KTH), Stockholm, Sweden.
2022 ~
Visting prof, Garvan Institute, Australia
2010 ~ 2021
Director National Genomics Infrastructure hosted at SciLifeLab
Short research summary
Joakim Lundeberg PhD, Professor in Molecular Biotechnology since 2000. JL was one of the co-founders of Science for Life Laboratory Sweden in 2010, a national and multi-university effort in large scale life sciences providing access to infrastructures such as genomics, proteomics, imaging, metabolomics and drug development. There are approximately 700 research scientists embedded in the infrastructure performing independent research. Dr Lundeberg has during the most recent years focused spatial transcriptomics technology, that enables detailed description of gene expression patterns in tissue sections. The spatially resolved transcriptomics was announced to be the Method of Year 2020 by Nature Methods and spatial transcriptomics is commercially available from 10X Genomics Inc as Visium. Dr Lundeberg has several publications demonstrating the development of the technology but also examples on the impact of the technology in biology. The current research focus on expanding the spatial modalities, developing new software tools and applications in human cell atlas, neurology and cancer.
Selected Publications
- Ståhl P, Salmén F, Vickovic S, Lundmark A, Fernández Navarro J, Magnusson J, Giacomello S, Asp M, Westholm JO, Huss M, Mollbrink A, Linnarsson S, Codeluppi S, Borg Å, Pontén F, Costea PI, Sahlén P, Mulder J, Bergmann O, Lundeberg J* and Frisén J . Visualization and analysis of gene expression in tissue sections by Spatial Transcriptomics. Science. 2016 Jul 1;353(6294):78-82. (* corresponding author).
- Asp M, Giacomello S, Fürth D, Reimegård J, Wärdell E, Custodio J, Salmén F, Sundström E, Åkesson E, Bienko M, Månsson-Broberg A, Ståhl PL, Sylvén C, and Lundeberg J*. An organ-wide gene expression atlas of the developing human heart. Cell 2019 Dec 12;179(7):1647-1660 (*corresponding author).
- Ji AL, Rubin AJ, Thrane K, Jiang S, Reynolds DL, Meyers RM, Guo MG, George BM, Mollbrink A, Bergenstråhle J, Larsson L, Bai Y, Zhu B, Bhaduri A, Meyers JM, Rovira-Clavé X, Hollmig ST, Aasi SZ, Nolan GP, Lundeberg J, and Khavari PA. Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma Cell. 2020 Jul 23;182(2):497-514.e22. doi: 10.1016/j.cell.2020.05.039. Epub 2020 Jun 23. PMID: 32579974
- Ortiz C, Navarro JF, Jurek A, Märtin A, Lundeberg J*, and Meletis K*. Molecular atlas of the adult mouse brain. Sci Adv. 2020 Jun 26;6(26):eabb3446. doi: 10.1126/sciadv.abb3446. eCollection 2020 Jun. PMID: 32637622 (*corresponding authors).
- Larsson L, Frisén J, Lundeberg J*. Spatially resolved transcriptomics adds a new dimension to genomics. Nat Methods. 2021 Jan;18(1):15-18. doi: 10.1038/s41592-020-01038-7. PMID: 33408402 (*corresponding author).
- Bergenstråhle L, He B, Bergenstråhle J, Abalo X, Mirzazadeh R, Thrane K, Ji AL, Andersson A, Larsson L, Stakenborg N, Boeckxstaens G, Khavari PA; Zou J, Lundeberg J* and Maaskola J. Super-resolved spatial transcriptomics by deep data fusion Nature Biotech 2021, Nov 29. doi: 10.1038/s41587-021-01075-3 (*corresponding author).
- Erickson A, He M, Berglund E, Marklund M, Mirzazadeh R, Schultz N, Bergenstråhle L, Kvastad L, Andersson A, Bergenstråhle J, Larsson L, Shamikh A, Basmaci E, Diaz De Ståhl T, Rajakumar T, Thrane K, Ji AL, Khavari PA, Tarish F, Tanoglidi A, Maaskola J, Colling R, Mirtti T, Hamdy FC, Woodcock DJ, Helleday T, Mills IG, Lamb AD*, and Lundeberg J*. The spatial landscape of clonal somatic mutations in benign and malignant tissue. Nature, 2022, in press
